张晓明研究员，科技部重点研发首席科学家。2007年获得法国巴黎第六大学免疫学博士学位，2007年至2012年在法国巴斯德研究所从事博士后研究。2012年加入研究所，担任 “B细胞与疾病免疫学研究组”研究组组长。此外还担任中国科学院分子病毒与免疫学重点实验室副主任，中国免疫学会青工委副主委等职务。
主持科技部重点研发计划，国家自然科学基金国际重点合作项目/面上项目、中国科学院先导项目、中国科学院前沿科学重点项目、中国科学院创新交叉团队项目、中国科学院对外合作重点项目、上海市科委基础重点项目等科研项目。
研究方向：
聚焦B细胞基础和疾病研究的领域难题，开展攻关研究。
1. B细胞及特定B细胞亚群命运决定的关键机制；
2. 人类重大疾病（系统性红斑狼疮、肝脏肿瘤、重大感染疾病等）的B细胞应答、靶向干预及创新抗体研究；
3. 衰老、代谢与B细胞应答；
4. 疾病单细胞多组学研究。
1. B细胞分化和创新抗体研究
建立了领域前沿的B细胞单细胞和人源抗体发现平台，针对人类重大疾病（肝脏肿瘤为代表的肿瘤疾病、系统性红斑狼疮为代表的自身免疫疾病、重大感染疾病）开展研究，鉴定出疾病特异性的B细胞亚群，揭示跨疾病抗体应答的共性和个性特征并探索内在机制，研发具有潜在治疗价值的人源单克隆抗体。
此外，对比研究胚胎和骨髓B细胞发育的前端事件，探索B细胞在中枢免疫器官的稳态发育和耐受打破机制。
2. 疾病单细胞组学研究
建立了基于高维流式细胞、单细胞测序和空间蛋白组学的“免疫细胞组学(Immune Cellomics)”研究平台，结合计算生物学整合建模策略，绘制人类健康和疾病状态下的精准免疫图谱，挖掘核心致病机制和新型疾病标志物。
代表性论文：（*通讯作者）
1. Ma JQ, Wu YC, Ma LF, …, , Guo GJ*, Zhang XM*, and Qiang Gao*. A blueprint for tumor-infiltrating B cells across human cancers. Science. 2024, 384, eadj4857. [IF=56.9]
2. Wu YC, Ma JQ, Yang XP,…, Jia Fan J*, Zhang XM*, and Gao Q*. Neutrophil profiling illuminates anti-tumor antigen-presenting potency. Cell. 2024, 187: 1422–1439. [IF=64.5]
3. Chen YM, Zha JL, Xu SQ,…, Li DF*, and Zhang XM*. Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation. Viruses. 2024, 16: 566. [IF=4.7]
4. Dong C, Guo YC, Chen ZC,…, Zhang XM*, Sheng ZZ*, and Gu ZF*. Single-cell profiling of bone marrow B cells uncovers early B cell developmental disorders associated with systemic lupus erythematosus. Arthritis Rheumatol. 2024, 76: 599-613. [IF=13.3]
5. Meng XH, Chen ZC, Li T, …, Zhang XM*, and Xiao LB*. Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/FGFR1 in Relapsed Rheumatoid Arthritis. Arthritis Rheumatol. 2024, 76: 32-47. [IF=13.3]
6. Fan FF, Gao J, Zhao Y, …, Zhang Y*, Zhang XM*, and Chen HQ*. Elevated Mast Cell Abundance is Associated with Enrichment of CCR2+ Cytotoxic T cells and Favorable Prognosis in Lung Adenocarcinoma. Cancer Res. 2023, 83: 2690-2703. [IF=13.312]
7. Meng L, Zha JL , Zhou BJ, …, Li DF*, Lavillette D* and Zhang XM*. A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy. PLoS Pathog. 2023, 19: e1011085. [IF=7.464]
8. Ye Y, Chen ZC, Jiang S, …, Fu Q*, and Zhang XM*. Single-cell Profiling Reveals Distinct Adaptive Immune Hallmarks in MDA5+ Dermatomyositis with Therapeutic Implications. Nat Commun. 2022, 13: 6458. [IF=17.694]
9. Ye Y, Zhang XL, Li T, …, Guo Q*, Fu Q* and Zhang XM*. Two Distinct Immune Cell Signatures Predict the Clinical Outcomes in Patients with MDA5 positive Dermatomyositis with Interstitial Lung Disease. Arthritis Rheumatol. 2022, 74: 1822–1832. [IF=13.3]
10. Wu YC, Yang SX, Ma JQ, …, Zhang XM*, and Gao Q*. Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level. Cancer Discov. 2022, 12: 134-153. [IF=38.272]
11. Song GH, Shi Y, Meng L, …, Fan J*, Zhang XM*, Xi RB*, and Gao Q*. Single-Cell Transcriptomic Analysis Reveals Two Molecularly and Clinically Distinct Subtypes of Intrahepatic Cholangiocarcinoma. Nat Commun. 2022, 13:1642. [IF=17.694]
12. Pu WL, Shi X, Yu PC,…, Zhang XM*, and Wang YL*. Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma. Nat Commun. 2021, 12: 6058. [IF=17.694]
13. Fu Q*, Zhang XM*. From blood to tissue: take a deeper look at B cells in lupus. Cell MolImmunol. 2021, 18: 2073–2074. [IF= 22.096]
14. Song GH, Shi Y, Zhang MY, …, Zhang XM*, Xi RB*, and Gao Q*. Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T cell subsets associated with disease progression. Cell Discov. 2020, 6: 90. [IF=38.079]
15. Wu CM, Fu Q, Guo Q, …, Bao CD*, and Zhang XM*. Lupus associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated. Ann Rheum Dis. 2019,78: 1090-1100. [IF=27.973]
16. Ma JQ, Zheng BH, Goswami S, …, Gao Q*, and Zhang XM*. PD1HiCD8+T Cells Correlate with Exhausted Signature and Poor Clinical Outcome in Hepatocellular Carcinoma. J ImmunoTher Cancer. 2019, 7: 331. [IF=12.469]
17. Duan M, Goswami S, Shi JY, …, Fan J*, Zhang XM*, and Gao Q*. Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma. Clin Cancer Res. 2019, 25: 3304-3316. [IF=13.801]
18. Liu M, Guo Q, Wu CM, …, Fu Q*, and Zhang XM*. Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients. Cell MolImmunol. 2019, 16: 367–379. [IF= 22.096]
19. Zhang Z, Ma LJ, Goswami S, …, Gao Q*, and Zhang XM*. Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinoma. Oncoimmunology. 2019, 8: e1571388. [IF=7.723]
20. Zhang XM, Zhivaki D, and Lo-Man R. Unique aspects of the perinatal immune system. Nat Rev Immunol. 2017,17:495-507. [IF=108.555]