酒亚明，博士生导师，中科院生物物理研究所与华中科技大学联合培养下获得生物物理专业博士学位，随后师从芬兰科学院院士Pekka Lappalainen教授进行博士后研究，主持芬兰国家科学院博后专项基金，后获得赫尔辛基大学细胞与分子生物学系助理教授教职。2018年在中科院上海巴斯德研究所建立病原宿主互作的细胞生物学及光学成像实验室，担任研究组长，致力于利用多种先进的生物成像技术研究细胞骨架的动态组装机制及在病原感染条件下的病理功能。
先后主持国家优秀青年科学基金项目、基金委重大研究计划项目、中科院率先行动计划项目（终期评估优秀）、中科院国际合作项目、上海市人才发展资金等重要科研项目。担任European Journal of Cell Biology 副主编，Journal of Cell Biology青年顾问委员会委员，Journal of Molecular Cell Biology、JoVE杂志编委，中国细胞生物学会细胞结构与行为分会副会长，上海市医学会医学病毒专科分会秘书，中国电镜学会共聚焦分会委员，中国生理学基质生物学分会委员等学术兼职。已在国际专业期刊发表五十余篇SCI研究论文，其中以通讯作者在Nature Communications，PNAS，Journal of Cell Biology, Current Biology, Science Bulletin, Nano Letters等杂志发表论文三十余篇，以共同作者在Nature Photonics，The EMBO Journal, Journal of Hepatology，PLoS Pathogens，Light: Science and Application等杂志发表论文十余篇。多篇论文被Faculty of 1000 Prime推荐，被多家新闻媒体报导，被Nature Reviews Molecular Cell Biology，Nature Cell Biology，Nature Materials等杂志点评引用，多篇工作被推荐为杂志封面论文。
一、欲善之事——我们关心的科学问题
细胞骨架体系对细胞结构（精细、动态）和功能（信号传导、感染免疫、转录翻译）起关键作用，也常常与其它亚细胞器、外界刺激同步协作。我们举几个例子来看看细胞骨架网络是如何帮助细胞实现其生理病理功能的：细胞的运动取决于微丝的组装及与中间丝的互作（癌细胞转移）；细胞分裂取决于依赖于微管的遗传物质分裂和依赖于微丝的胞质重组（癌细胞无限增殖）、细胞的生物力学感受取决于微丝应力纤维的平衡维持和中间丝的韧性（细胞物理化学微环境）、细胞应激下的完整性维持及应答取决于中间丝的动态重组（病原感染）等。
我们以细胞骨架为主要研究对象，希望从分子-亚细胞器-细胞-活体尺度完整理解感染条件下的细胞生物学过程，改进和完善相关生物成像方法，不懈探索病原体感染与宿主细胞互作的病理基础与规律，致力于为相关疾病的精准治疗提供新的药物靶点和治疗策略。
二、先利之器——我们使用的实验方法
只有整合细胞生物学、分子病毒学、细菌学、多种组学（成像组学、蛋白质组学、转录组学、翻译后修饰组学等）、深度学习和数据分析等多种技术手段，我们才能兼顾空间和时间信息并识别出关键因子，从而在获得连贯完整理解的同时筛选鉴定关键靶向因子，进而提供有效的抗感染治疗策略。我们按如下框架进行探索：
√ 用基因编辑、免疫印迹、蛋白纯化、感染模型构建、分子标记等细胞生物学手段针对宿主细胞的动态应答进行研究；
√ 用活病原感染、假病毒/复制子等工具构建、病原突变操作、病原分离和组份扩增等病原学手段针对病原感染的生命周期进行研究；
√ 用超高分辨活细胞成像、高通量成像筛选、单子分定位、光电联合成像、图像处理与建模等多种先进的生物成像手段针对病原宿主互作的时空动态过程进行研究
三、细胞骨架的多才多艺——我们开展的具体课题
上述研究框架已经让我们获得一些出人意料的发现，比如发现了宿主细胞中间丝对病原体复制的调控机制，提出了中间丝在感染中作为结构支撑和调节因子的双重功能（PNAS, 2022; Journal of Cell Science, 2020; Journal of Cell Science, 2022）；发现了宿主细胞或癌细胞的迁移模式调控迁移体生成的现象，从中间丝角度拓展了研究新亚细胞器的方法（Journal of Cell Biology, 2022, top ten best paper of the year）；阐明了微丝-中间丝互作的结构基础和信号机制（Current Biology, 2019; iScience, 2020）。 未来，我们将致力于利用多种先进的生物成像技术研究细胞骨架的动态组装机制及在病原感染条件下的病理功能，旨在突破我们对病原体利用宿主细胞骨架促进自身感染策略的认识，并为相关感染性疾病的治疗提供新的候选药物和有效治疗策略。
√ 从微观角度研究细胞骨架的动态性及对细胞结构和行为的调控等生理功能
√ 从宿主细胞角度研究其在感染条件下的动态应答和致病机制等病理功能
√ 从病原体角度研究不同病原（新发突发多发）感染天然宿主细胞和免疫细胞的完整连贯完成过程
√ 相关光学显微成像技术和探针的新功能改进和新技术研发
四、独乐乐——我们的代表性论文
1. Zhao S#, Miao C#, Li Z#, Gao X#, Eriksson J*, Jiu Y* “Vimentin cage - a double-edged sword in host anti-infection defense”. Current Opinion in Cell Biology. Jan 2;86:102317. doi: 10.1016/j.ceb.2023.102317. 2024.
2. Huang X, Xing Y, Cui Y, Ji B, Ding B, Zhong J, Jiu Y* “Actomyosin dependent cell contractility orchestrates zika virus infection”. Journal of Cell Science. Aug 25:jcs.261301. doi: 10.1242/jcs.261301. 2023.
3. Zhang Y#, Zhang X#, Li Z#, Zhao W#, Yang H, Zhao S, Tang D, Zhang Q, Liu H, Li H, Li B, Lappalainen P, Cui Z*, Jiu Y* “Single particle tracking reveals SARS-CoV-2 regulating and utilizing dynamic filopodia for viral invasion”. Science Bulletin. Aug 15. doi.: 10.1016/j.scib.2023.08.031. 2023.
4. Xing Y#, Chen R#, Li F#, Xu B, Han L, Jiu Y*, Zhong J*, Zhou G* “Discovery of a fused bicyclic derivative of 4-hydroxypyrrolidine and imidazolidinone as a new anti-HCV agent”. Virology. Jul 20. Doi: 10.1016/j.virol.2023.07.012. 2023.
5. Wang Y#, Liang H#, Liu Y#, Bao Q, Yang S, Xu X, Chen Y, Liu W, Shi X, Shi Y, Liu X, Liu B, Hao H*, Jiu Y*, Liu Y* “Lamin A/C and vimentin as a coordinated regulator during amoeboid migration in microscale confined microenvironments”. Nano Letters. Jul 17. doi: 10.1021/acs.nanolett.3c02096. 2023.
6. Zhao W#, Zhao S#, Han Z#, Ding X#, Hu G, Qu L, Huang Y, Wang X, Mao H, Jiu Y, Hu Y, Tan J, Ding X*, Chen L*, Guo C*, Li H* “Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging”. Nature Photonics. Jun 15. doi: 10.1038/s41566-023-01234-9. 2023.
7. Mei J#, Huang X#, Fan C#, Fang J, Jiu Y* “Cytoskeleton network participates in the anti-infection responses of macrophage”. BioEssays. May 31:e2200225. doi: 10.1002/bies.202200225. 2023.
8. Zhao S#, Xu Q#, Cui Y#, Yao S, Jin S, Zhang Q, Wen Z, Ruan H, Liang X, Chao Y, Sansonetti P, Wei K*, Tang H*, Jiu Y* “Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection”. Nature Communications. Jan 30;14(1):478. doi: 10.1038/s41467-023-36123-w. 2023.
9. Zhang Y#, Zhao S, Li Y, Feng F, Li M, Xue Y, Cui J, Xu T, Jin X*, Jiu Y* “Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication”. Proc Natl Acad Sci U S A. Feb 22;119(8):e2113909119. doi: 10.1073/pnas.2113909119. 2022.
10. Fan C#, Shi X, Zhao K, Wang L, Shi K, Liu Y, Li H, Ji B, Jiu Y* “Cell migration orchestrates migrasome formation by shaping retraction fibers” Journal of Cell Biology. Apr 4;221(4): e202109168. doi: 10.1083/jcb.202109168. 2022. 封面论文，获年度十佳论文专题报道
11. Shi X#, Tang D#, Xing Y#, Zhao S, Fan C, Zhong J, Cui Y*, Shi K*, Jiu Y* “Actin nucleator formins regulate the tension-buffering function of caveolin-1” Journal of Molecular Cell Biology. Jan 29;13(12):876-888. doi: 10.1093/jmcb/mjab070. 2021. 封面论文
12. Liu W#, Tang D#, Xu X, Liu Y*, Jiu Y* “How physical factors coordinate virus infection： a perspective from mechanobiology”. Frontiers in Bioengineering and Biotechnology. Oct 29;9:764516. doi: 10.3389/fbioe.2021.764516. 2021.
13. Shi X#, Wen Z, Wang Y, Liu Y, Shi K, Jiu Y* “Feedback-driven mechanisms between phosphorylated caveolin-1 and contractile actin assemblies instruct persistent cell migration” Frontiers in Cell and Developmental Biology. Apr 12;9:665919. doi: 10.3389/fcell.2021.665919. 2021.
14. Wen G#, Li S, Wang L, Chen X, Sun Z, Liang Y, Jin X, Xing Y, Jiu Y, Tang Y, Li H* “High-fidelity structured illumination microscopy by point-spread-function engineering” Light: Science & Application. Apr 1;10(1):70. doi: 10.1038/s41377-021-00513-w. 2021.
15. Zhang Y#, Wen Z, Shi X, Liu Y, Eriksson J*, Jiu Y* “The diverse roles and dynamic rearrangement of vimentin during virus infection”. Journal of Cell Science. Nov 5;134(5):jcs250597. doi: 10.1242/jcs.250597. 2020.
16. Zhao S#, Shi X#, Zhang Y#, Wen Z, Cai J, Gao W, Xu J, Zheng Y, Ji B, Cui Y, Shi K, Liu Y, Li H, Jiu Y*, “Myosin-18B promotes mechanosensitive CaMKK2-AMPK-VASP regulation of contractile actin stress fibers”. iScience. Apr 24;23(4):100975. doi: 10.1016/j.isci.2020.100975. 2020.
17. Wen Z#, Zhang Y#, Lin Z, Shi K, Jiu Y*, “Cytoskeleton - a crucial key in host cell for coronavirus infection”. Journal of Molecular Cell Biology. Dec;12(12):968-79. doi: 10.1093/jmcb/mjaa042. 2020.
18. Xing Y#, Wen Z#, Gao W, Lin Z, Zhong J, Jiu Y*, “Multifaceted functions of host cell caveolae/caveolin-1 in virus infections”. Viruses. Apr 26; 12(5):E487. doi: 10.3390/v12050487. 2020.
19. Kumari R#, Jiu Y, Carman P, Tojkander S, Kogan K, Varjosalo M, Gunning P, Dominguez R, Lappalainen P* “Tropomodulins control balance between protrusive and contractile structures in migrating cells by stabilizing actin-tropomyosin filaments”. Current Biology. Mar 9;30(5):767-778.e5. doi: 10.1016/j.cub.2019.12.049. 2020.
20. Zhao S#, Cai J#, Zhang X, Cui J, Jiu Y* “Different formins restrict localization of distinct tropomyosins on dorsal stress fibers in osteosarcoma cells”. Cytoskeleton (Hoboken). Jan;77(1-2):16-24. doi: 10.1002/cm.21588. 2020.
21. Jiu Y#*, Kumari R, Fenix A, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette D, Lappalainen P* “Myosin-18B promotes the assembly of myosin II stacks to drive maturation of contractile actomyosin bundles”. Current Biology. Jan 7;29(1):81-92.e5. doi: 10.1016/j.cub.2018.11.045. 2019.
22. Shi X#, Zhao S, Cai J, Wong G, Jiu Y* “Active FHOD1 promotes the formation of functional actin stress fibers”. Biochemical Journal. Oct 30;476(20):2953-2963. doi: 10.1042/BCJ20190535. 2019. 封面论文
23. Li J#, Gao W#, Zhang Y#, Cheng F, Eriksson J, Etienne-Manneville S, Jiu Y* “Engagement of vimentin intermediate filaments in hypotonic stress”. Journal of Cellular Biochemistry. Aug;120(8):13168-13176. doi: 10.1002/jcb.28591. 2019.
24. Deng L#, JiangW, Wang X, Merz A, Hiet M, ChenY, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G* “Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes”. Journal of Hepatology. Jul;71(1):52-61. doi: 10.1016/j.jhep.2019.03.006. 2019.
25. Li J#, Zou Y, Li Z, Jiu Y* “Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling”. Science China Life Sciences. Oct;62(10):1368-1374. doi: 10.1007/s11427-018-9488-1. 2019.
26. Zhang Y#, Gao W, Li J, Wu W, Jiu Y* “The role of host cytoskeleton in flavivirus infection”. Virologica Sinica. 2019 Feb;34(1):30-41. doi: 10.1007/s12250-019-00086-4. 2019. 封面论文
27. Liu X#, Salokas K, Tamene F, Jiu Y, Weldatsadik R, Varjosalo M* “An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations”. Nature Communications. Mar 22; 9(1):1188. doi: 10.1038/s41467-018-03523-2. 2018.
28. Jiu Y#*, Peranen J, Schaible N, Cheng F, Eriksson J, Krishnan R, Lappalainen P* “Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA”. Journal of Cell Science. Jan 18; 130(5): 892-902. doi: 10.1242/jcs.196881. 2017.
29. Jiu Y#, Lehtimaki J, Tojkander S, Cheng F, Jaalinoja H, Liu X, Varjosalo M, Eriksson J, Lappalainen P* “Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers”. Cell Reports. Jun 16; 11(10):1511-1518. doi: 10.1016/j.celrep.2015.05.008. 2015.
30. Weinheimer I#, Jiu Y#, Rajami M#, Matilainen O, Kallijarvi J, Cuellar W, Lu R, Saarma M, Holmberg C, Jantti J, Valkonen J* “Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants”. PLoS Pathogens. Mar 6; 11(3):e1004711. doi: 10.1371/journal.ppat.1004711. 2015.
31. Yu Y#, Wang L#, Jiu Y#, Zhan Y, Liu L, Xia Z, Song E, Xu P*, Xu T* “HID-1 is a novel player in the regulation of neuropeptide sorting”. Biochemical Journal. Feb 24; 434(3):383-390. doi: 10.1042/BJ20110027. 2011.
32. Jiu Y#, Yue Y#, Yang S#, Liu L, Yu J, Zhang R, Wu Z*, Xu T* “Insulin-like signaling pathway for decision making behavior in C. elegans”. Protein Cell. Jan;1(1):75-81. doi: 10.1007/s13238-010-0003-4. 2010.
33. Jiu Y#, Hu Z#, Liu J#, Wu Z*, Xu T* “α-LTX and α-LTXN4C induce [Ca2+]i elevation through different mechanisms in pancreatic β cells”. Chinese Science Bulletin. Jan; 51(2):158-163. doi: 10.1007/s11434-005-1029-5. 2006.
34.李剑，酒亚明*。中间纤维的功能和研究进展。中国细胞生物学学报，41(3). doi: 10.11844/cjcb.2019.03.0283. 2019 (特邀综述、40周年纪念专刊)
五、众乐乐——诚招人才
生物学家西德尼·布伦纳说“科学的进步依赖于新技术，新发现，新的理念，并且大致以此为序。” 我们欢迎具有细胞生物学、病毒学、细菌学、生物成像、微流控芯片、生物化学等背景的优秀硕士、博士、博士后、助理研究员和副研究员加入团队协力攻关共同开展科学研究，也欢迎联系毕业设计等。