免疫表观基因组学
1996–2000 北京大学 生化与分子生物学专业 学士
2000–2005 北京大学 核酸分子生物学专业 博士
2005–2011 美国国家健康研究院（National Institutes of Health） 博士后
2012–2017 中国科学院一马普学会计算生物学伙伴研究所 研究员
2017–2024 中国科学院上海营养与健康研究所 研究员
2024－至今 中国科学院上海免疫与感染研究所 研究员
1) Zhang G, Li Y#, and Wei G# (2023) Multi-omic analysis reveals dynamic changes of three-dimensional chromatin architecture during T cell differentiation. Communications Biology. 6: 773.
2) Zhang Y, Cao X, Gao Z, Ma X, Wang Q, Xu X, Cai X, Zhang Y, Zhang Z, Wei G # and Wen B # (2023) MATR3-antisense LINE1 RNA meshwork scaffolds higher-order chromatin organization. EMBO reports. 24: e57550.
3) Cao X, Wen Y, Li Y, Ma X, Jing Q, Jiang L # and Wei G # (2023) PfSET2 is involved in genome organization of var gene family in Plasmodium falciparum. Microbiology Spectrum. 11: e0389122.
4) Wang X, Yan J, Ye Z, Zhang Z, Wang S, Hao S, Shen B, Wei G # (2022) Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells. Front Cell Dev Biol. 5: 10:974750.
5) Ma X, Cao X, Zhu L, Li Y, Wang X, Wu B, Wei G # and Hui L # (2021) Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity. National Science Reviews. 9: nwab230.
6) Wang X, Yan J, Shen B, Wei G. # (2021). Integrated Chromatin Accessibility and Transcriptome landscapes of Doxorubicin-resistant breast cancer cells. Front Cell Dev Biol. 9: 708066.
7) Lu B, Liu M, Gu L, Li Y, Shen S, Guo G, Wang F, He X, Zhao Y, Shang X, Wang L, Yang G, Zhu Q, Cao J, Jiang C, Culleton R, Wei G# and Zhang Q# (2021) The Architectural factor HMGB1 is involved in genome organization in the human malaria parasite Plasmodium falciparum. mBio. 12: e00148-21.
8) Lai Y, Cao X, Chen J, Wang L, Wei G #, Wang S# (2020) Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection. Science Advances. 6: eaaz1659.
9) Zhang Y, Zou X, Qian W, Weng X, Zhang L, Zhang L, Wang S, Cao X, Ma L, Wei G #, Wu Y #, Hou Z #. (2019) Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis. Cell Death Differ. 26: 565-579.
10) Ji S, Zhu L, Gao Y, Zhang X, Yan Y, Cen J, Li R, Zeng R, Liao L, Hou C, Gao Y, Gao S, Wei G# and Hui L# (2017) Baf60B-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening. Cell Research. 27: 642-656.
11) Gao Y, Zhang X, Zhang L, Cen J, Ni X, Liao X, Yang C, Li Y, Chen X, Zhang Z, Shu Y, Cheng X, Hay D, Lai D, Pan G, Wei G# and Hui L#. (2017) Distinct gene expression and epigenetic signatures in hepatocyte-like cells produced by different strategies from the same donor. Stem Cell Reports. 9: 1813-1824.
12) Li Q, Lei P, Zhao Q, Li L, Wei G# and Wu M#. (2017) Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation. Epigenomics. 9:1077-1092.
13) Lv X, Han Z, Chen H, Yang B, Yang X, Xia Y, Pan C, Fu L, Zhang S, Han H, Wu M, Zhou Z, Zhang L, Li L, Wei G# and Zhao Y#. (2016) A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Research. 26: 529-542.
14) Zhao Q, Lei P, Zhang X, Zheng J, Wang H, Zhao J, Li Y, Ye M, Li L, Wei G# and Wu M#. (2016) Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clinical Epigenetics. 8: 34.
15) Gu J, Wang D, Zhang J, Zhu Y, Li Y, Chen H, Shi M, Wang X, Shen B, Deng X, Zhan Q, Wei G# and Peng C#. (2016) GFRalpha2 prompts cell growth and chemo-resistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer. Cancer Letters. 380: 434-441.
16) Chepelev I*, Wei G*, Wangsa D, Tang Q and Zhao K (2012). Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Research. 22: 490-503.
17) Wei G*, Abraham B*, Yagi R*, Jothi R*, Cui K, Sharma S, Narlikar L, Northrup D, Tang Q, Paul W, Zhu J and Zhao K (2011). Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity. 35: 299-311.
18) Wei G*, Wei L*, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh T, Watford W, Schones D, Peng W, Sun H, Paul W, O’Shea J and Zhao K (2009). Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity. 30: 155-167.
1.系统性研究T细胞分化过程中表观遗传修饰，细胞特异性转录因子，染色质三维结构的变化规律与调控机制（Immunity, 2009; Immunity, 2011; Cell Research, 2012; Communications, 2023）
2.系统性解析成纤维细胞向肝细胞转分化过程中表观遗传信息以及染色质三维结构的动态变化，揭示细胞可塑性的染色质内在因素（Cell Research, 2017; Stem Cell Reports, 2017; National Science Review, 2021）
3.探究疟原虫三维基因组的动态调控规律以及对var基因的转录调控（mBio, 2021; Microbiology Spectrum, 2023）
课题组研究聚焦于免疫系统的表观基因组学。我们利用多组学技术手段结合计算生物学数据分析，探究免疫细胞分化，免疫记忆，免疫衰老以及肿瘤免疫应答过程中表观遗传信息的动态变化与调控机制。我们的研究包括以下主要研究方向：
（1）完善并开发单细胞多组学技术与分析方法，特别是单细胞三维基因组技术，用来解析免疫细胞三维基因组的异质性与动态变化。
（2）解析T细胞分化，T细胞耗竭以及T细胞衰老等过程中三维基因组动态变化及其如何调控特定基因转录的分子机制。
（3）利用单细胞多组学技术探究转座子来源的肿瘤新抗原，开发肿瘤特异性新疫苗。
实验室成员（Lab member）
招生信息（admission information）
欢迎具有生物学、生物信息学以及基础医学背景的优秀学生加入本团队攻读硕士和博士研究生。
