闫燕博士2016年毕业于荷兰莱顿大学，获微生物生态学博士学位。2017年加入美国哈佛大学公共卫生学院从事博士后研究，导师是人类微生物组学计划（Human Microbiome Project I/II）奠基人Curtis Huttenhower教授。自2022年起担任研究所研究员、研究组长、博士生导师，以第一作者或通讯作者在Cell & Host Microbe, Genome Medicine, ISME Journal, Microbiome等期刊发表论文20余篇。曾荣获美国Charles A. King科研基金，美国Keystone Trainee Award，哈佛大学公共卫生学院科研基金，荷兰莱顿大学博士基金等，担任iMeta青年编委，Nutrition & Metabolism 副主编。

Nutrition & Metabolism 副主编

Epidemiological risk factors correlate of the cancer microbiome

· Yan Y, Drew DA, Markowitz A, Lloyd-Price J, Abu-Ali G, Nguyen LH, Tran C, Chung DC, Gilpin KK, Meixell D, Parziale M, Schuck M, Patel Z, Richter JM, Kelsey PB, Garrett WS, Chan AT, Stadler ZK, Huttenhower C. Structure of the mucosal and stool microbiome in Lynch syndrome. Cell Host & Microbe. 2020. PMID: 32240601

· Yan Y, Nguyen LH, Franzosa EA, Huttenhower C. Strain-level epidemiology of the human microbiome. Genome Medicine. 2020. PMID: 27098841

· Young C, Wood HM, Seshadri RA, Nang PV, Vaccaro C, Melendez LC, Bose M, Doi MV, Pin？ero TA, Valladares CT, Arguero J, Balaguer AF, Thompson KN, Yan Y, Huttenhower C, Quirke P. The colorectal cancer (CRC)-associated faecal microbiome of developing countries resembles that of developed countries. Genome Medicine. PMID: 33593386

· Young C, Wood HM, Seshadri RA, Nang PV, Vaccaro C, Melendez LC, Bose M, Doi MV, Pin？ero TA, Valladares CT, Arguero J, Balaguer AF, Thompson KN, Yan Y, Huttenhower C, Quirke P. Microbiome analysis of over 2000 NHS Bowel Cancer Screening Programme (NHSBCSP) samples shows the potential to improve screening accuracy. Clinical Cancer Research. PMID: 33658300

· Nguyen LH, Ma W, Wang DD, Cao Y, Mallick H, Gerbaba TK, Lloyd-Price J, Abu-Ali G, Hall AB, Sikavi D, Drew DA, Mehta RS, Arze C, Joshi AD, Yan Y, Branck T, DuLong C, Ivey KL, Ogino S, Rimm EB, Song M, Garrett WS, Izard J, Huttenhower C, Chan AT. Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology. PMID: 31972239

· Sikavi DR, Nguyen LH, Haruki K, Ugai T, Ma WJ, Wang DD, Thompson K, Yan Y, Branck T, Wilkinson J, Akimoto N, Zhong R, Lau MC, Mima K, Kosumi K, Morikawa T, Rimm EB, Garrett WS, Izard J, Cao Y, Song MY, Huttenhower C, Ogino SJ, Chan AT. The sulfur microbial diet and risk of colorectal cancer by molecular subtypes and intratumoral microbial species in adult men. 2021. Clinical and Translational Gastroenterology. PMID: 34333506

The role of microbiome in cancer therapeutic response

· Yan Y. The microbial code and cancer immunotherapy outcome. Cell Host & Microbe, 2023. PIMD: 37442095

· Ya Wang, Kelsey N. Thompson, Yan Y, Meghan I.Short, Yancong Zhang, Eric A.Franzosa, Jiaxian Shen, Erica M, Hartmann and Curtis Huttenhower. RNA-based amplicon sequencing is ineffective in measuring metabolic activity in environmental microbial communities. Microbiome. 2023. PIMD: 37312147

· Wang DD, Nguyen LH, Li YP, Yan Y, Ma WJ, Rinott E, Ivey K, Shai I, Willett WC, Hu FB, Eric B. Rimm EB, Stampfer MJ, Chan AT, Huttenhower C. The gut microbiome modifies the protective effects of a Mediterranean diet against cardiometabolic disease risk. Nature Medicine. PMID: 33574608

· Spencer C. et al. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science. PMID: 34941392

· Zhang YC, Thompson K, Branck T, Yan Y, Nguyen LH, Franzosa EA, Huttenhower C. Metatranscriptomics for the human microbiome and microbial community functional profiling. Annual Review of Biomedical Data Science. PMID: 34465175

Assembly and dynamics of gut microbiome in host ecological microenvironment

· Yan Y, Kuramae EE, de Hollander M, Klinkhamer PGL, Van Veen JA. Functional traits dominate the diversity-related selection of bacterial communities in the rhizosphere. ISME J. 2017. PMID: 27482928

· Yan Y, Klinkhamer PGL, Van Veen JA, Kuramae EE. Environmental filtering: A case of bacterial community assembly in soil. Soil Biology and Biochemistry, Volume 136, September 2019, 107531. Web of science

· Yan Y, Kuramae EE, de Hollander M, Klinkhamer PGL, Van Veen JA. Revisiting the dilution procedure used to manipulate microbial biodiversity in terrestrial systems. Applied Environmental Microbiology. 2015. PMID: 25888175

· Wang Y, Yan Y, Thompson K, Bae S, Shen JX, Vlamakis H, Hartman EM, Huttenhower C. Characterizing microbial community viability from built environment using propidium monoazide. Microbiome. PMID: 33478576

　　微生物作为生态系统中的重要组成部分，其产生的活性小分子物质及代谢产物介导宿主与微生物、微生物物种之间的相互关联，影响宿主稳态和机体健康。肠道菌群是寄居在人体肠道中的微生物群落，细胞总数约为人体自身细胞数量的十倍，参与整个机体营养吸收和复杂的生理生化过程。肠道菌群结构失衡和功能紊乱将直接或间接影响包括肠道肿瘤在内的多种恶性疾病发生。然而，微生物在肠道肿瘤中的致癌机制仍有很多未知，这也局限了基于微生物针对肿瘤预防和治疗的方案开发和应用。研究组致力于利用微生物学、生物信息学、分子生物学等手段，解析肠道微生物组与宿主免疫在肿瘤微环境的全新调控机制。

　　本课题组将开展以下几方面研究：

　　1）肠道肿瘤微生物组的流行病学相关因素

　　2）肠道微生物及代谢产物与肿瘤微环境的互作机制

　　3）肠道稳态的维持与靶向微生物治疗肿瘤的方案开发

　　本实验室致力于培养对科研有浓厚兴趣、具有辩证思维能力的科研团队。现有博士后、博士研究生、本科科研实习、科研助理等岗位，诚挚欢迎勇于挑战、富有创造性的您申请加入！详细招聘信息请参考团队网站：https://yyanlab.github.io/ 

实验室成员(Lab member)

科研助理：赵亮

国科大博士研究生：胡语歆

国科大硕士研究生：林鑫

同济大学博士研究生：喇焕之

实习生：潘薇

欢迎优秀的博士生毕业生来课题组做博士后。

欢迎优秀学生加入本团队攻读硕士和博士研究生。

欢迎大学二年级（含）以上同学进入实验室参与有关科研学术工作，或联系毕业设计等。