1990.9-1995.7  北京大学  本科

1999.1-2003.7  新加坡国立大学  博士

2002.10-2005.12美国哈佛医学院  交换学者

2006.01-2013.01美国Emory大学疫苗中心  博士后

2013.2-2023.7   中国科学院上海巴斯德研究所 研究员

2023.7－至今    中国科学院上海免疫与感染研究所 研究员

中国医药生物技术协会移植技术分会委员

中国人体健康科技促进会鼻咽癌专委会委员

1. Ding Ma, Siyu chen, Jinxiao Ren, YuChen Pei, CongWei Jiang, Shen Zhao, Yi Xiao, XiaoEn Xu, GuangYu Liu, Xin Hu, XiaoZhen Liang, KeDa Yu, DaQiang Li, YiZhou Jiang, ZhiMing Shao. Molecular features and functional implications of germline variants in triple-negative breast cancer. Journal of the National Cancer Institute. 2020 Nov 5, https://doi.org/10.1093/jnci/djaa175.

2. Shuai Liu, Zhangmengxue Lei1, Jie Li, Liu Wang, Ran Jia, Zhongshun Liu, Congwei Jiang, Ying Gao, Mu Liu, Linlin Kuang, Zhikang Qian, Dongming Zhou, Samuel H. Speck, Xiaozhen Liang*. Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation. PLoS Pathogens. 2020 16(7):e1008701.

3. Ran Jia, Xiangshi Wang, Pengcheng Liu, Xiaozhen Liang, Yanling Ge, He Tian, Hailing Chang, Hao Zhou, Mei Zeng, Jin Xu. Mild cytokine elevation, moderate CD4 + T cell response and abundant antibody production in Children with COVID-19. Virol Sin. 2020 Jul 22;1-10. doi: 10.1007/s12250-020-00265-8.

4. Zhihua Zhang, Bin Li , Jing Fu, Rong Li, Feiyang Diao, Caihong Li , Biaobang Chen, Jing Du, Zhou Zhou, Jian Mu, Zheng Yan, Ling Wu, Shuai Liu, Wenjing Wang, Lin Zhao, Jie Dong, Lin He, Xiaozhen Liang, Yanping Kuang, Xiaoxi Sun, Qing Sang, Lei Wang. Bi-allelic Missense Pathogenic Variants in TRIP13 Cause Female Infertility Characterized by Oocyte Maturation Arrest. Am J Hum Genet. 2020 May 29; S0002-9297(20)30148-8.

5. Ran Jia, Shuai Liu, Jin Xu, Xiaozhen Liang*. IL16 deficiency enhances Th1 and cytotoxic T lymphocyte response against influenza A virus infection.  Bioscience Trends. 2019, 201; 13(6):516-522.  

6. Wenting Zhu, Jiaxin Li, Rui Zhang, Yixiang Cai, Changwan Wang, Shishi Qi, She Chen, Xiaozhen Liang, Nan Qi, Fajian Hou. TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity. EMBO J. 2019 Aug 7:e102075. doi: 10.15252/embj.2019102075.

7. Ying Gao, Liu Wang, Zhangmengxue Zhang, Jie Li, Xiaozhen Liang*. IRF4 promotes Epstein-barr virus activation in Burkitt’s lymphoma cells. J. Gen. Virol. 2019 Mar 25. doi: 10.1099/jgv.0.001249.

8. Shuai Liu, Long Li, Lingbing Tan, Xiaozhen Liang*. Inhibition of herpes simplex virus-1 replication by natural compound honokiol. Virol. Sin. 2019 Mar 26. doi: 10.1007/s12250-019-00104-5.

9. Fang Zhang, Deguang Liang, Xiaoxi Lin, Zhe Zou, Rui Sun, Xing Wang, Xiaozhen Liang, Kenneth M. Kaye, Ke Lan. NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS Pathogens. 2019 Feb 27;15(2):e1007628.

10. Weihong Zhang, Yongfen Xu, Fanfan Zhao, Marion Tarbe, Shuru Zhou, Weihong Wang, Shengyuan Zhang, Wei Zhang, Qiuping  Xu, Lina Shi, Feng Yuan, Xinwen Lin, Shuai Liu, Jing Sun, Jincun Zhao, Yaling Yang, Xiaozhen Liang, Jin Zhong, Gang Long, Chengfeng Qin, Qibin Leng, Hong Tang. The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection. Science Bulletin. 2019, https://doi.org/10.1016/j.scib.2019.11.006.

11. Xingchen Zhou, Zhongshun Liu, Shuai Liu, Chaocan Zhang, Xiaozhen Liang*. ER stress regulation of B cell receptor-mediated gammaherpesvirus lytic replication by ATF4 and CHOP. Journal of Biological Chemistry 2018 Feb 23;293(8):2801-2814.

12. Xingchen Zhou, Wenbo Jiang, Zhongshun Liu, Shuai Liu, Xiaozhen Liang*. Virus Infection and Death Receptor-Mediated Apoptosis. Viruses. 2017 Oct 27;9(11).

13. Sihan Dong, J Craig Forrest, Xiaozhen Liang*. Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases. Adv Exp Med Biol. 2017;1018:225-236.

14. Sihan Dong, Lingbing Tan, Guifang Chen, Xiaozhen Liang*. CD95-CD95L interaction mediates the growth control of MHV68 immortalized B cells by cytotoxic T cells. Virol Sin. 2017 Jun;32(3):257-259.

15. Ran Jia, Jin Xu, Lu Lu, Xiaozhen Liang, Zhiwu Sun, Lingbing Tan, Menghua Xu, Liyun Su. Poly(U) and CpG ameliorate the unbalanced T cell immunity and pneumonia of mice with RSV vaccine-enhanced disease. Bioscience Trends. 2017 Sep 12;11(4):450-459.

16. Jia Ran, Lu Lu, Liang Xiaozhen, Sun Zhiwu, Tan Lingbing, Xu Menghua, Su Liyun, Xu Jin. Establishment and analysis of murine model of RSV vaccine-enhanced disease. Journal of Microbes and Infections. 2016;11(3):144-52.

17. Lingbing Tan, Chaocan Zhang, Julien Dematos, Linlin Kuang, Jae U Jung and Xiaozhen Liang*. CD95 signaling inhibits B cell receptor-mediated gammaherpesviral replication in apoptosis-resistant B lymphoma cells. Journal of Virology. 2016 Nov 1;90(21):9782-9796.  

近期我们研究发现了疱疹病毒感染与致瘤的新的分子机制，以及T细胞免疫调控疱疹病毒相关淋巴瘤的机制。在此基础上构建和改造溶瘤病毒以及病毒特异性T细胞，结合临床病人样本和动物模型，分析新的调节分子在基因和免疫治疗相关肿瘤中的作用和潜在应用。

实验室主要研究方向是疱疹病毒感染与致病机制，T细胞免疫调控病毒与相关肿瘤的分子机制，宿主抗病毒的免疫反应。 探索病毒特异性T细胞在免疫治疗相关肿瘤中的作用与应用。

实验室成员(Lab member)

助理研究员：邝林林

硕士研究生：刘三三

博士研究生：高颖

硕博连读研究生：雷张梦雪，姜从伟，方子豪，郭景奥

毕业研究生(Graduate student)

招生信息(admission information)

欢迎具有生物学，病毒学， 免疫学等学科背景的优秀学生加入本团队攻读硕士和博士研究生。欢迎大学三年级（含）以上同学进入实验室参与有关科研学术工作，或联系毕业设计等。